Written by my friend Constance Hayden
Pinky and the Brain was a spin-off of the hit cartoon show Animaniacs. They were regular side-characters on the show and the basic premise was that they wanted to take over the world. The only catch is that they are mice living in a lab.
It's pretty self-explanatory, but Pinky was the dopey one and Brain was, well, he was the brainy one. Brain's mission in life was to escape his wretched entrapment as a lab mouse and take over the world. Every single episode was about Brain trying to come up with an elaborate plan to escape, only to have Pinky do something dumb to spoil it all.
Brain hated Pinky because of how he always messed up his plans for world domination, but he still put up with him and acted as his mentor. Pinky was pretty much mentally retarded, honestly. He wasn't just dopey, there was clearly something wrong with his brain and he was always making goofy noises at random times and the way he talked was just insanely stupid. But that's what made it funny.
Like Animaniacs, Pinky and the Brain also had a very catchy opening tune that always got stuck in your head. In fact, it's now stuck in mine. I will probably have to watch an episode of Real L Word on Directv to get it out of my head.